Quantitative monitoring of omeprazole synthesis reaction and crystallization by in-line Raman spectroscopy

The development of a quantitative in-line Raman spectroscopic method for in situ monitoring
of the active pharmaceutical ingredient, omeprazole synthesis reaction and crystallization is
described. In-line monitoring was performed using a dispersive Raman instrument. Prior to
reaction monitoring, the reaction components were characterized off-line by means of Raman
and NMR spectroscopy. The spe…