Role of gene polymorphisms of proinflammantory cytokines IL-1 in primary knee and hip osteoarthritis

Objectives. Osteoarthritis (OA) is a frequent joint disease with complex genetic risk. Genetic predisposition to the complex hereditary disease like OA of the large joints (hip and knee) includes the interleukin-1 gene (IL1) cluster on chromosome 2. Also, one of the loci that could predispose the development of OA is located on chromosome 6 (6p12.3-q13). Near this locus is a gene, which encodes th…